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News about Crigler-Najjar syndrome from the following sources:

- Hepatology

Crigler‚ÄźNajjar Syndrome Type 1: Pathophysiology, Natural History, and Therapeutic Frontier (pdf)

- Genethon announces gene therapy trial for Crigler-Najjar syndrome
- World Journal of Gastroenterology 2008; 14(22): 3464-3470, June 2008
Liver cell transplantation for Crigler-Najjar syndrome type I: Update and perspectives, by P.A. Lysy et al.
- Transplantation Proceedings 2008; 40, 1148–1150, May 2008
Treatment of Crigler-Najjar Syndrome Type 1 by hepatic progenitor cell transplantation: a simple procedure for management of hyperbilirubinemia, by A.A. Khan et al.
- The Baptist Standard , 26 June 2008
Out of the Blue: Rare syndrome affects Pleasanton youth minister’s daughters, by Gerge Henson.
- European Medicine Agency (EMEA), 16 January 2008
Heterologous human adult liver derived stem cells are designated by EMEA as an orphan medicinal product for the treatment of Crigler-Najjar syndrome.
- Associated content, 04 July 2007
The Blue disease: Crigler-Najjar syndrome, by Lu Baker.
- The SanLuisObispo, 23 May 2007
The Blue Light Kids, by Helen O’Neill - Associated Press.
- Article from The European Journal of Pediatrics
Very interesting paper by Dr. Strauss from The Clinic for Special Children titled: "Management of hyperbilirubinemia and prevention of kernicterus in 20 patients with Crigler-Najjar disease"
- eMedicine
Glucuronyl Transferase Deficiency.
- Proc Natl Acad Sci U S A. 2005 March 7
Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector.

- New York Times:
by Lisa Belkin, on November 6, 2005.
"A Doctor for the Future".

- Cell Translantation :
by Ambrosino et al., 2005.
Isolated hepatocyte transplantation for Crigler-Najjar type I.

- Health Reporter:
by Amanda Dunn, December 2004.
Hepatocyte transplantation. Rama's dream of a carefree life is coming true.

- Science
by Gary Taubes, December 2002, Vol. 298, 2116-2120. The strange case of Chimeraplasty.

- Mosaic:
by Leslie Virostek, November 2001.
Dr. Holmes Morton: An innovative pediatrician in an insular community

- E-medicine Journal:
by Alessio Pigazzi, July 18, 2001. Vol. 2, number 7.
Crigler-Najjar  Syndrome.

- E-medicine Journal:
by  Shirley Donelson,  May 3, 2001. Vol. 2, number 5.
Bilirubin, impaired conjugation

- Saudi Medical Journal:
Management of Crigler-Najjar Syndrome type I.
by Al-Shurafa H.A. et al. Department of Hepatobiliary Surgery and Transplantation, University Hospital Hamburg-Eppendorf, Martini Street 52, 20246 Hamburg, Germany. Tel. +49 (40) 42803 6135/6136. Fax. +49 (40) 42803 3431. Email: [email protected]

From Saudi. Med. J. (2001). 22(6):486-489.
Crigler-Najjar Syndrome type I is a rare congenital disease with high mortality and morbidity rates due to brain complications. It has been treated by life-long phototherapy until the era of liver transplantation. Liver transplantation is currently the only curative treatment for this syndrome. Liver transplantation prevents the severe neurological complications that are the main cause of life-long disability in Crigler-Najjar Syndrome type I. The ideal age for transplantation is 3-5 years. Despite the advent of auxiliary transplantation we believe that orthotopic liver transplantation is the optimal treatment and the ideal method of liver transplantation for Crigler-Najjar Syndrome type I.

- World Press Photo of the Year 2001:
First Prize Category Portraits: Young Crigler-Najjar Syndrome Patient.

- Human Mutation:
by Kadakol et al., (2000). 16: 297-306.
"Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotype".

- Fortune:
by M. Wadman, Vol. 141 No. 9,  May  2000, pp. 178-182.
"Can Gene Therapy Cure This Child?".

- Pediatrics:
by  J. F. Lucey,  G. K. Suresh,  A. Kappas,  Pediatrics Vol. 105 No. 5 May 2000, pp. 1152-1154.
"Crigler-Najjar Syndrome, 1952-2000: learning from parents and patients about a very rare disease and using the Internet to recruit patients for studies".

- Hep News:
report from Reuters Health, April 2000, from The Hepatitis Information Network.
"Liver cell injections may help liver disease patients".

- The Scientist:
by Paul Smaglik on Jan. 10, 2000 (The Scientist 14[1]:13).
"Chimeraplasty Potential. As research advances, hopes rise, but efficiency and safety are still concerns".

by J. Stephenson, (1999) Volume 281 Issue 2.
"New method to repair faulty genes stirs interest in chimeraplasty technique".

- European Journal of pediatrics:
by P. L. M. Jansen, (1999) Volume 158 Issue 14 pp S089-S094.
"Diagnosis and management of Crigler-Najjar syndrome".

- PKU News:
by  Dr. R. Michael Blaese, from the Fall 1999 issue of National PKU News. "Gene Repair For Inborn Errors of Metabolism: What is it and when might it become available?".

- USA Today:
by T. Friendg, Aug. 31, 1999
"For first time, scientists repair gene defect".

- New York Times:
by Denise Grady on June 29, 1999.
"At Gene Therapy's Frontier, the Amish Build a Clinic".

- The Lancet:
by R.W.I. Cookie on May 29, 1999. "New approach to prevention of kernicterus."

- Washington Post:
reports by Associated Press and Reuters on May 14, 1998, Page A10.
"Injection of liver cells improves girl's health".

To request a copy of any of the aforementioned paper contact .


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